Loading
TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, animal model 0.41, genetic association 0.02, somatic mutation 0.98). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma.
In plain words · TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
TRIM33 (E3 ubiquitin-protein ligase TRIM33) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Lung cancer, Breast cancer, Colorectal cancer and 1 more.
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway.
No product in this corpus aims at TRIM33 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Venturini et al, Oncogene, 1999, "TIF1gamma, a novel member of the transcriptional intermediary factor 1 family". Source.
Sources: HGNC HGNC:16290 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UPN9 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000197323 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: colorectal cancer 0.50, breast cancer 0.53, lung cancer 0.53 (GraphQL API, CC0)); IntOGen TRIM33 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signalling cascade. Plays a role in the control of cell proliferation. Location: Nucleus (UniProt). Locus 1p13.2 (HGNC).
Query for this target: (TITLE:"TRIM33" OR ABSTRACT:"TRIM33" OR TITLE:"tripartite motif containing 33" OR ABSTRACT:"tripartite motif containing 33" OR TITLE:"E3 ubiquitin-protein ligase TRIM33" OR ABSTRACT:"E3 ubiquitin-protein ligase TRIM33" OR TITLE:"TIF1GAMMA" OR ABSTRACT:"TIF1GAMMA" OR TITLE:"FLJ11429" OR ABSTRACT:"FLJ11429" OR TITLE:"KIAA1113" OR ABSTRACT:"KIAA1113") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TRIM33, not a curated reading list.
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Medulloblastoma, IntOGen.