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CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Medulloblastoma.
In plain words · CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
CCAR1 (Cell division cycle and apoptosis regulator protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter.
No product in this corpus aims at CCAR1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2002. Earliest sequence paper UniProt cites for the protein: Tian et al, 2002, "TAZ binding partners identified by mass spectrometry". Source.
Sources: HGNC HGNC:24236 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IX12 (protein name, function text, keywords and locations (REST API)); IntOGen CCAR1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation. May be involved in apoptosis signalling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Location: Cytoplasm, perinuclear region (UniProt). Locus 10q21.3 (HGNC).
Query for this target: (TITLE:"CCAR1" OR ABSTRACT:"CCAR1" OR TITLE:"cell division cycle and apoptosis regulator 1" OR ABSTRACT:"cell division cycle and apoptosis regulator 1" OR TITLE:"Cell division cycle and apoptosis regulator protein 1" OR ABSTRACT:"Cell division cycle and apoptosis regulator protein 1" OR TITLE:"CARP1" OR ABSTRACT:"CARP1" OR TITLE:"CARP-1" OR ABSTRACT:"CARP-1" OR TITLE:"uc.285+" OR ABSTRACT:"uc.285+") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCAR1, not a curated reading list.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.