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TCF4 (Transcription factor 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.
In plain words · TCF4 (Transcription factor 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
TCF4 (Transcription factor 4) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation.
No product in this corpus aims at TCF4 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1990. Earliest sequence paper UniProt cites for the protein: Henthorn et al, Nucleic Acids Res, 1990, "Sequence of the cDNA encoding ITF-2, a positive-acting transcription factor". Source.
Sources: HGNC HGNC:11634 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P15884 (protein name, function text, keywords and locations (REST API)); IntOGen TCF4 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcription factor that binds to the immunoglobulin enhancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription. Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'. Location: Nucleus (UniProt). Locus 18q21.2 (HGNC).
Query for this target: (TITLE:"TCF4" OR ABSTRACT:"TCF4" OR TITLE:"transcription factor 4" OR ABSTRACT:"transcription factor 4" OR TITLE:"Transcription factor 4" OR ABSTRACT:"Transcription factor 4" OR TITLE:"SEF2-1B" OR ABSTRACT:"SEF2-1B" OR TITLE:"ITF2" OR ABSTRACT:"ITF2" OR TITLE:"bHLHb19" OR ABSTRACT:"bHLHb19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TCF4, not a curated reading list.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.