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ZNF274 (Neurotrophin receptor-interacting factor homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Medulloblastoma.
In plain words · ZNF274 (Neurotrophin receptor-interacting factor homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
ZNF274 (Neurotrophin receptor-interacting factor homolog) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma.
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression.
No product in this corpus aims at ZNF274 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Petroni et al, DNA Seq, 1998, "Computer sequence analysis of human highly conserved zinc finger modules". Source.
Sources: HGNC HGNC:13068 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96GC6 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF274 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions. Location: Cytoplasm; Nucleus, nucleolus (UniProt). Locus 19q13.43 (HGNC).
Query for this target: (TITLE:"ZNF274" OR ABSTRACT:"ZNF274" OR TITLE:"zinc finger protein 274" OR ABSTRACT:"zinc finger protein 274" OR TITLE:"Neurotrophin receptor-interacting factor homolog" OR ABSTRACT:"Neurotrophin receptor-interacting factor homolog" OR TITLE:"ZKSCAN19" OR ABSTRACT:"ZKSCAN19" OR TITLE:"ZSCAN51" OR ABSTRACT:"ZSCAN51") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF274, not a curated reading list.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.