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FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
Essential for Golgi structural integrity.
IntOGen calls it a driver in 3 cohorts (3 activating, 0 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma, Prostate Adenocarcinoma.
In plain words · FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
FAM174B (Membrane protein FAM174B) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Medulloblastoma and Paediatric low-grade glioma.
Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt).
No product in this corpus aims at FAM174B yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:34339 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q3ZCQ3 (protein name, function text, keywords and locations (REST API)); IntOGen FAM174B (driver in 3 cohorts (Act 3, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Essential for Golgi structural integrity. Location: Cell membrane; Golgi apparatus (UniProt). Locus 15q26.1 (HGNC).
Query for this target: (TITLE:"FAM174B" OR ABSTRACT:"FAM174B" OR TITLE:"family with sequence similarity 174 member B" OR ABSTRACT:"family with sequence similarity 174 member B" OR TITLE:"Membrane protein FAM174B" OR ABSTRACT:"Membrane protein FAM174B" OR TITLE:"LOC400451" OR ABSTRACT:"LOC400451" OR TITLE:"MGC102891" OR ABSTRACT:"MGC102891") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAM174B, not a curated reading list.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.