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KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity.
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.
In plain words · KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate.
No product in this corpus aims at KDM3B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:1337 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7LBC6 (protein name, function text, keywords and locations (REST API)); IntOGen KDM3B (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity. Location: Nucleus (UniProt). Locus 5q31.2 (HGNC).
Query for this target: (TITLE:"KDM3B" OR ABSTRACT:"KDM3B" OR TITLE:"lysine demethylase 3B" OR ABSTRACT:"lysine demethylase 3B" OR TITLE:"Lysine-specific demethylase 3B" OR ABSTRACT:"Lysine-specific demethylase 3B" OR TITLE:"KIAA1082" OR ABSTRACT:"KIAA1082" OR TITLE:"NET22" OR ABSTRACT:"NET22" OR TITLE:"C5orf7" OR ABSTRACT:"C5orf7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KDM3B, not a curated reading list.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.