{"entity":{"id":"kdm3b","kind":"target","name":"KDM3B","aka":["lysine demethylase 3B","Lysine-specific demethylase 3B","KIAA1082","NET22","C5orf7","JMJD1B"],"tldr":"KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.","summary":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1337","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1337"},{"label":"UniProt Q7LBC6","url":"https://www.uniprot.org/uniprotkb/Q7LBC6/entry"},{"label":"NCBI Gene 51780","url":"https://www.ncbi.nlm.nih.gov/gene/51780"},{"label":"Ensembl ENSG00000120733","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120733"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["medulloblastoma","paediatric-low-grade-glioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"KDM3B","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1337","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1337","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7LBC6","url":"https://www.uniprot.org/uniprotkb/Q7LBC6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen KDM3B","url":"https://www.intogen.org/search?gene=KDM3B","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:1337","ensembl":"ENSG00000120733","uniprot":"Q7LBC6","entrez":"51780","firstDescribed":1999,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Kikuno et al, DNA Res, 1999, \"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10470851/","biology":"Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity. Location: Nucleus (UniProt). Locus 5q31.2 (HGNC).","whereFound":["Medulloblastoma: IntOGen driver in 1 cohort (MBL)","Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/kdm3b/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"paediatric-low-grade-glioma","kind":"cancer","name":"Paediatric low-grade glioma","route":"/cancers/paediatric-low-grade-glioma/"}]}}