Loading
LDB1 (LIM domain-binding protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1.
IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.
In plain words · LDB1 (LIM domain-binding protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
LDB1 (LIM domain-binding protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions.
No product in this corpus aims at LDB1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1998. Earliest sequence paper UniProt cites for the protein: Semina E.V. et al, Mamm. Genome, 1998, "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI". Source.
Sources: HGNC HGNC:6532 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86U70 (protein name, function text, keywords and locations (REST API)); IntOGen LDB1 (driver in 3 cohorts (Act 0, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. Location: Nucleus (UniProt). Locus 10q24.32 (HGNC).
Query for this target: (TITLE:"LDB1" OR ABSTRACT:"LDB1" OR TITLE:"LIM domain binding 1" OR ABSTRACT:"LIM domain binding 1" OR TITLE:"LIM domain-binding protein 1" OR ABSTRACT:"LIM domain-binding protein 1" OR TITLE:"CLIM2" OR ABSTRACT:"CLIM2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LDB1, not a curated reading list.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Medulloblastoma, IntOGen.
Shares Paediatric low-grade glioma, Medulloblastoma, IntOGen.