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HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity.
Open Targets scores its association with cancer at 0.75 (direct and indirect evidence; datatypes affected pathway 0.83, literature 0.86, genetic association 0.00, somatic mutation 0.83, animal model 0.62). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Medulloblastoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Upper Tract Urothelial Carcinoma.
In plain words · HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
HIP1 (Huntingtin-interacting protein 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Breast cancer, Lung cancer and 3 more.
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner.
No product in this corpus aims at HIP1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Kalchman M.A. et al, Nat. Genet, 1997, "HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain". Source.
Sources: HGNC HGNC:4913 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00291 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000127946 (association with cancer (MONDO_0004992) 0.75; per-cancer scores at or above 0.5: skin cancer 0.50, breast cancer 0.56, lung cancer 0.53 (GraphQL API, CC0)); IntOGen HIP1 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). Location: Cytoplasm; Nucleus; Endomembrane system; Cytoplasmic vesicle, clathrin-coated vesicle membrane (UniProt). Locus 7q11.23 (HGNC).
Query for this target: (TITLE:"HIP1" OR ABSTRACT:"HIP1" OR TITLE:"huntingtin interacting protein 1" OR ABSTRACT:"huntingtin interacting protein 1" OR TITLE:"Huntingtin-interacting protein 1" OR ABSTRACT:"Huntingtin-interacting protein 1" OR TITLE:"ILWEQ" OR ABSTRACT:"ILWEQ") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HIP1, not a curated reading list.
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Breast cancer (all types).
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Open Targets Platform.
Shares Medulloblastoma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Lung cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Uterine carcinosarcoma, IntOGen.