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WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.
In plain words · WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
WNT1 (Proto-oncogene Wnt-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Uterine carcinosarcoma.
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation.
No product in this corpus aims at WNT1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1985. Earliest sequence paper UniProt cites for the protein: van Ooyen et al, EMBO J, 1985, "The nucleotide sequence of the human int-1 mammary oncogene; evolutionary conservation of coding and non-coding sequences". Source.
Sources: HGNC HGNC:12774 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P04628 (protein name, function text, keywords and locations (REST API)); IntOGen WNT1 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signalling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signalling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis. Location: Secreted, extracellular space, extracellular matrix; Secreted (UniProt). Locus 12q13.12 (HGNC).
Query for this target: (TITLE:"WNT1" OR ABSTRACT:"WNT1" OR TITLE:"Wnt family member 1" OR ABSTRACT:"Wnt family member 1" OR TITLE:"Proto-oncogene Wnt-1" OR ABSTRACT:"Proto-oncogene Wnt-1" OR TITLE:"INT1" OR ABSTRACT:"INT1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WNT1, not a curated reading list.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.