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BCLAF1 (Bcl-2-associated transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Gastric & gastro-oesophageal junction cancer, Acute myeloid leukaemia and 2 more.
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
IntOGen calls it a driver in 5 cohorts (4 activating, 1 loss-of-function), covering Acute Myeloid Leukaemia, Melanoma, Prostate Adenocarcinoma, Stomach Adenocarcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour.
In plain words · BCLAF1 (Bcl-2-associated transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Gastric & gastro-oesophageal junction cancer, Acute myeloid leukaemia and 2 more.
BCLAF1 (Bcl-2-associated transcription factor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Gastric & gastro-oesophageal junction cancer, Acute myeloid leukaemia and 2 more.
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.
No product in this corpus aims at BCLAF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1996, "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:16863 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYF8 (protein name, function text, keywords and locations (REST API)); IntOGen BCLAF1 (driver in 5 cohorts (Act 4, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Location: Cytoplasm; Nucleus; Nucleus speckle; Nucleus, nucleoplasm (UniProt). Locus 6q23.3 (HGNC).
Query for this target: (TITLE:"BCLAF1" OR ABSTRACT:"BCLAF1" OR TITLE:"BCL2 associated transcription factor 1" OR ABSTRACT:"BCL2 associated transcription factor 1" OR TITLE:"Bcl-2-associated transcription factor 1" OR ABSTRACT:"Bcl-2-associated transcription factor 1" OR TITLE:"KIAA0164" OR ABSTRACT:"KIAA0164") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BCLAF1, not a curated reading list.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen.
Shares Uterine carcinosarcoma, IntOGen, Melanoma, Prostate cancer.