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FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B".
IntOGen calls it a driver in 9 cohorts (3 activating, 6 loss-of-function), covering Head and Neck Squamous Cell Carcinoma, Lung Squamous Cell Carcinoma, Pancreatic Adenocarcinoma, Endometrial Carcinoma, Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumour, Well-Differentiated Thyroid Cancer.
In plain words · FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
FAM135B (family with sequence similarity 135 member B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Pancreatic ductal adenocarcinoma, Endometrial cancer and 4 more.
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B". Locus 8q24.23 (HGNC).
No product in this corpus aims at FAM135B yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1999. Earliest sequence paper UniProt cites for the protein: Mei et al, 1999. Source.
Sources: HGNC HGNC:28029 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q49AJ0 (protein name, function text, keywords and locations (REST API)); IntOGen FAM135B (driver in 9 cohorts (Act 3, LoF 6); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for Q49AJ0; HGNC names it "family with sequence similarity 135 member B". Locus 8q24.23 (HGNC).
Query for this target: (TITLE:"FAM135B" OR ABSTRACT:"FAM135B" OR TITLE:"family with sequence similarity 135 member B" OR ABSTRACT:"family with sequence similarity 135 member B" OR TITLE:"C8ORFK32" OR ABSTRACT:"C8ORFK32") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAM135B, not a curated reading list.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Pancreatic ductal adenocarcinoma.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Non-small-cell lung cancer.
Shares Papillary thyroid cancer, Thyroid cancer, Endometrial cancer, IntOGen.
Shares Thyroid cancer, IntOGen, Head and neck squamous cell carcinoma, Non-small-cell lung cancer.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Non-small-cell lung cancer.
Shares Uterine carcinosarcoma, IntOGen.