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ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
GTPase-activating protein for Rho family members.
IntOGen calls it a driver in 7 cohorts (3 activating, 4 loss-of-function), covering Bladder Urothelial Carcinoma, Pancreatic Adenocarcinoma, Plasma Cell Myeloma, Pleural Mesothelioma, Well-Differentiated Thyroid Cancer.
In plain words · ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
ARHGAP5 (Rho GTPase-activating protein 5) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Multiple myeloma, Pancreatic ductal adenocarcinoma and 4 more.
GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt).
No product in this corpus aims at ARHGAP5 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1995. Earliest sequence paper UniProt cites for the protein: Burbelo P.D. et al, J. Biol. Chem, 1995, "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking". Source.
Sources: HGNC HGNC:675 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13017 (protein name, function text, keywords and locations (REST API)); IntOGen ARHGAP5 (driver in 7 cohorts (Act 3, LoF 4); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
GTPase-activating protein for Rho family members. Location: Cytoplasm; Cell membrane (UniProt). Locus 14q12 (HGNC).
Query for this target: (TITLE:"ARHGAP5" OR ABSTRACT:"ARHGAP5" OR TITLE:"Rho GTPase activating protein 5" OR ABSTRACT:"Rho GTPase activating protein 5" OR TITLE:"Rho GTPase-activating protein 5" OR ABSTRACT:"Rho GTPase-activating protein 5" OR TITLE:"RhoGAP5" OR ABSTRACT:"RhoGAP5" OR TITLE:"p190-B" OR ABSTRACT:"p190-B" OR TITLE:"p190BRhoGAP" OR ABSTRACT:"p190BRhoGAP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ARHGAP5, not a curated reading list.
Shares Papillary thyroid cancer, Pleural mesothelioma, Mesothelioma, Thyroid cancer.
Shares Pleural mesothelioma, Mesothelioma, Bladder & urothelial cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, Bladder & urothelial cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.