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TAF15 (TATA-binding protein-associated factor 2N) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Mesothelioma and Pleural mesothelioma.
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Bladder Urothelial Carcinoma, Pleural Mesothelioma.
In plain words · TAF15 (TATA-binding protein-associated factor 2N) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Mesothelioma and Pleural mesothelioma.
TAF15 (TATA-binding protein-associated factor 2N) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Bladder & urothelial cancer, Mesothelioma and Pleural mesothelioma.
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'.
No product in this corpus aims at TAF15 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Morohoshi et al, Genomics, 1996, "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins". Source.
Sources: HGNC HGNC:11547 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92804 (protein name, function text, keywords and locations (REST API)); IntOGen TAF15 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Location: Nucleus; Cytoplasm (UniProt). Locus 17q12 (HGNC).
Query for this target: (TITLE:"TAF15" OR ABSTRACT:"TAF15" OR TITLE:"TATA-box binding protein associated factor 15" OR ABSTRACT:"TATA-box binding protein associated factor 15" OR TITLE:"TATA-binding protein-associated factor 2N" OR ABSTRACT:"TATA-binding protein-associated factor 2N" OR TITLE:"hTAFII68" OR ABSTRACT:"hTAFII68" OR TITLE:"RBP56" OR ABSTRACT:"RBP56" OR TITLE:"Npl3" OR ABSTRACT:"Npl3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TAF15, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, Bladder & urothelial cancer, IntOGen.