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PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.
In plain words · PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt).
No product in this corpus aims at PI4KA yet. Kinases are switched on by binding ATP inside the cell, so most drugs are small molecules shaped to plug that ATP pocket.
First described 1994. Earliest sequence paper UniProt cites for the protein: Wong et al, J. Biol. Chem, 1994, "Cloning and characterization of a human phosphatidylinositol 4-kinase". Source.
Sources: HGNC HGNC:8983 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P42356 (protein name, function text, keywords and locations (REST API)); IntOGen PI4KA (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt). Locus 22q11.21 (HGNC).
Query for this target: (TITLE:"PI4KA" OR ABSTRACT:"PI4KA" OR TITLE:"phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"phosphatidylinositol 4-kinase alpha" OR TITLE:"Phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"Phosphatidylinositol 4-kinase alpha" OR TITLE:"PI4K-ALPHA" OR ABSTRACT:"PI4K-ALPHA" OR TITLE:"pi4K230" OR ABSTRACT:"pi4K230" OR TITLE:"PIK4CA" OR ABSTRACT:"PIK4CA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PI4KA, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.