Loading
PI4KA (Phosphatidylinositol 4-kinase alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate. Location: Cytoplasm; Cell membrane (UniProt). Locus 22q11.21 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"PI4KA" OR ABSTRACT:"PI4KA" OR TITLE:"phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"phosphatidylinositol 4-kinase alpha" OR TITLE:"Phosphatidylinositol 4-kinase alpha" OR ABSTRACT:"Phosphatidylinositol 4-kinase alpha" OR TITLE:"PI4K-ALPHA" OR ABSTRACT:"PI4K-ALPHA" OR TITLE:"pi4K230" OR ABSTRACT:"pi4K230" OR TITLE:"PIK4CA" OR ABSTRACT:"PIK4CA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PI4KA, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/pi4ka.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pi4ka.json. Licence CC BY-NC 4.0.