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SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Pleural Mesothelioma.
In plain words · SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons.
No product in this corpus aims at SRGAP3 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1997. Earliest sequence paper UniProt cites for the protein: Ishikawa et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:19744 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43295 (protein name, function text, keywords and locations (REST API)); IntOGen SRGAP3 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons. Locus 3p25.3 (HGNC).
Query for this target: (TITLE:"SRGAP3" OR ABSTRACT:"SRGAP3" OR TITLE:"SLIT-ROBO Rho GTPase activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase activating protein 3" OR TITLE:"SLIT-ROBO Rho GTPase-activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase-activating protein 3" OR TITLE:"KIAA0411" OR ABSTRACT:"KIAA0411" OR TITLE:"MEGAP" OR ABSTRACT:"MEGAP" OR TITLE:"ARHGAP14" OR ABSTRACT:"ARHGAP14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRGAP3, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.