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CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond.
IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Pleural Mesothelioma.
In plain words · CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins.
No product in this corpus aims at CYP2C8 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1987. Earliest sequence paper UniProt cites for the protein: Okino S.T. et al, J. Biol. Chem, 1987, "Characterization of multiple human cytochrome P-450 1 cDNAs. The chromosomal localization of the gene and evidence for alternate RNA splicing". Source.
Sources: HGNC HGNC:2622 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10632 (protein name, function text, keywords and locations (REST API)); IntOGen CYP2C8 (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward oestrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 10q23.33 (HGNC).
Query for this target: (TITLE:"CYP2C8" OR ABSTRACT:"CYP2C8" OR TITLE:"cytochrome P450 family 2 subfamily C member 8" OR ABSTRACT:"cytochrome P450 family 2 subfamily C member 8" OR TITLE:"Cytochrome P450 2C8" OR ABSTRACT:"Cytochrome P450 2C8" OR TITLE:"CPC8" OR ABSTRACT:"CPC8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP2C8, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen, Melanoma.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen, Melanoma.