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FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.91, animal model 0.57, genetic association 0.76, somatic mutation 0.17). IntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia, Pleural Mesothelioma.
In plain words · FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
FLG (Filaggrin) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Mesothelioma, Acute myeloid leukaemia and 2 more.
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt).
No product in this corpus aims at FLG yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1989. Earliest sequence paper UniProt cites for the protein: McKinley-Grant L.J. et al, Proc. Natl. Acad. Sci. U.S.A, 1989, "Characterization of a cDNA clone encoding human filaggrin and localization of the gene to chromosome region 1q21". Source.
Sources: HGNC HGNC:3748 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P20930 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000143631 (association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: melanoma 0.55, skin cancer 0.63 (GraphQL API, CC0)); IntOGen FLG (driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Location: Cytoplasmic granule (UniProt). Locus 1q21.3 (HGNC).
Query for this target: (TITLE:"FLG" OR ABSTRACT:"FLG" OR TITLE:"filaggrin" OR ABSTRACT:"filaggrin" OR TITLE:"Filaggrin" OR ABSTRACT:"Filaggrin" OR TITLE:"FLG1" OR ABSTRACT:"FLG1" OR TITLE:"FLG-1" OR ABSTRACT:"FLG-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FLG, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, Skin cancer (all types), IntOGen.
Shares Pleural mesothelioma, Mesothelioma, Skin cancer (all types), IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen, Melanoma.
Shares Pleural mesothelioma, Mesothelioma, Skin cancer (all types), IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.