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PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2".
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pleural Mesothelioma.
In plain words · PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt).
No product in this corpus aims at PDZD2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1997. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". Source.
Sources: HGNC HGNC:18486 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15018 (protein name, function text, keywords and locations (REST API)); IntOGen PDZD2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
UniProt has no function text for O15018; HGNC names it "PDZ domain containing 2". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt). Locus 5p13.3 (HGNC).
Query for this target: (TITLE:"PDZD2" OR ABSTRACT:"PDZD2" OR TITLE:"PDZ domain containing 2" OR ABSTRACT:"PDZ domain containing 2" OR TITLE:"PDZ domain-containing protein 2" OR ABSTRACT:"PDZ domain-containing protein 2" OR TITLE:"KIAA0300" OR ABSTRACT:"KIAA0300" OR TITLE:"PDZK3" OR ABSTRACT:"PDZK3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PDZD2, not a curated reading list.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.
Shares Pleural mesothelioma, Mesothelioma, IntOGen.