{"entity":{"id":"pdzd2","kind":"target","name":"PDZD2","aka":["PDZ domain containing 2","PDZ domain-containing protein 2","KIAA0300","PDZK3"],"tldr":"PDZD2 (PDZ domain-containing protein 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma.","summary":"UniProt has no function text for O15018; HGNC names it \"PDZ domain containing 2\".\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18486"},{"label":"UniProt O15018","url":"https://www.uniprot.org/uniprotkb/O15018/entry"},{"label":"NCBI Gene 23037","url":"https://www.ncbi.nlm.nih.gov/gene/23037"},{"label":"Ensembl ENSG00000133401","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000133401"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"PDZD2","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:18486","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18486","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O15018","url":"https://www.uniprot.org/uniprotkb/O15018/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen PDZD2","url":"https://www.intogen.org/search?gene=PDZD2","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:18486","ensembl":"ENSG00000133401","uniprot":"O15018","entrez":"23037","firstDescribed":1997,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1997, \"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9205841/","biology":"UniProt has no function text for O15018; HGNC names it \"PDZ domain containing 2\". Location: Nucleus; Cytoplasm; Endoplasmic reticulum; Secreted (UniProt). Locus 5p13.3 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/pdzd2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}