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SRGAP3 (SLIT-ROBO Rho GTPase-activating protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma and Pleural mesothelioma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signalling in neurons. Locus 3p25.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"SRGAP3" OR ABSTRACT:"SRGAP3" OR TITLE:"SLIT-ROBO Rho GTPase activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase activating protein 3" OR TITLE:"SLIT-ROBO Rho GTPase-activating protein 3" OR ABSTRACT:"SLIT-ROBO Rho GTPase-activating protein 3" OR TITLE:"KIAA0411" OR ABSTRACT:"KIAA0411" OR TITLE:"MEGAP" OR ABSTRACT:"MEGAP" OR TITLE:"ARHGAP14" OR ABSTRACT:"ARHGAP14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SRGAP3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/srgap3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/srgap3.json. Licence CC BY-NC 4.0.