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PABPC1 (Polyadenylate-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Bladder & urothelial cancer and 5 more.
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo.
Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.00, somatic mutation 0.69). IntOGen calls it a driver in 8 cohorts (8 activating, 0 loss-of-function), covering Basal Cell Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Plasma Cell Myeloma, Upper Tract Urothelial Carcinoma and others.
In plain words · PABPC1 (Polyadenylate-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Bladder & urothelial cancer and 5 more.
PABPC1 (Polyadenylate-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Bladder & urothelial cancer and 5 more.
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability.
No product in this corpus aims at PABPC1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1987. Earliest sequence paper UniProt cites for the protein: Grange et al, Nucleic Acids Res, 1987, "Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif". Source.
Sources: HGNC HGNC:8554 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P11940 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070756 (association with cancer (MONDO_0004992) 0.59; (GraphQL API, CC0)); IntOGen PABPC1 (driver in 8 cohorts (Act 8, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Location: Cytoplasm; Cytoplasm, Stress granule; Nucleus; Cell projection, lamellipodium (UniProt). Locus 8q22.3 (HGNC).
Query for this target: (TITLE:"PABPC1" OR ABSTRACT:"PABPC1" OR TITLE:"poly A binding protein cytoplasmic 1" OR ABSTRACT:"poly A binding protein cytoplasmic 1" OR TITLE:"Polyadenylate-binding protein 1" OR ABSTRACT:"Polyadenylate-binding protein 1" OR TITLE:"PABP1" OR ABSTRACT:"PABP1" OR TITLE:"PABPL1" OR ABSTRACT:"PABPL1" OR TITLE:"PAB1" OR ABSTRACT:"PAB1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PABPC1, not a curated reading list.
Shares Papillary thyroid cancer, Thyroid cancer, Bladder & urothelial cancer, IntOGen.
Shares Basal cell carcinoma, Thyroid cancer, IntOGen, Open Targets Platform.
Shares Thyroid cancer, Bladder & urothelial cancer, Hepatocellular carcinoma, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Open Targets Platform.
Shares Thyroid cancer, Hepatocellular carcinoma, IntOGen, Open Targets Platform.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen.
Shares Papillary thyroid cancer, Thyroid cancer, IntOGen, Diffuse large B-cell lymphoma.