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ZFHX3 (Zinc finger homeobox protein 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 5 more.
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signalling can repress the transcription of AFP via its interaction with SMAD2/3.
Open Targets scores its association with cancer at 0.81 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.67, somatic mutation 0.92). IntOGen calls it a driver in 17 cohorts (4 activating, 13 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Diffuse Large B-Cell Lymphoma, NOS, Hepatocellular Carcinoma, Osteosarcoma, Plasma Cell Myeloma and others.
In plain words · ZFHX3 (Zinc finger homeobox protein 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 5 more.
ZFHX3 (Zinc finger homeobox protein 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 5 more.
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence.
No product in this corpus aims at ZFHX3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1991. Earliest sequence paper UniProt cites for the protein: Morinaga et al, Mol. Cell. Biol, 1991, "A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers". Source.
Sources: HGNC HGNC:777 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15911 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140836 (association with cancer (MONDO_0004992) 0.81; per-cancer scores at or above 0.5: colorectal cancer 0.53, gastric cancer 0.51, prostate cancer 0.67, endometrial cancer 0.59, melanoma 0.52, thyroid cancer 0.50 (GraphQL API, CC0)); IntOGen ZFHX3 (driver in 17 cohorts (Act 4, LoF 13); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signalling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. Location: Nucleus; Cytoplasm (UniProt). Locus 16q22.2-q22.3 (HGNC).
Query for this target: (TITLE:"ZFHX3" OR ABSTRACT:"ZFHX3" OR TITLE:"zinc finger homeobox 3" OR ABSTRACT:"zinc finger homeobox 3" OR TITLE:"Zinc finger homeobox protein 3" OR ABSTRACT:"Zinc finger homeobox protein 3" OR TITLE:"ZNF927" OR ABSTRACT:"ZNF927" OR TITLE:"FLJ26184" OR ABSTRACT:"FLJ26184" OR TITLE:"ATBF1" OR ABSTRACT:"ATBF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZFHX3, not a curated reading list.
Shares Thyroid cancer, Hepatocellular carcinoma, IntOGen, Multiple myeloma.
Shares Thyroid cancer, Bladder & urothelial cancer, Hepatocellular carcinoma, IntOGen.
Shares Thyroid cancer, Endometrial cancer, Bladder & urothelial cancer, IntOGen.
Shares Thyroid cancer, Hepatocellular carcinoma, IntOGen, Open Targets Platform.
Shares Thyroid cancer, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Thyroid cancer, Endometrial cancer, IntOGen, Open Targets Platform.
Shares Thyroid cancer, Bladder & urothelial cancer, IntOGen, Breast cancer (all types).
Shares Thyroid cancer, Endometrial cancer, Open Targets Platform.