DataLocalised prostate cancer, high and very high risk

Direct links plus the targets, companies, and technologies of this cancer's products.

• What this page is called in the NHS: Cambridge Prognostic Groups 4 and 5. NICE NG131 1.2.15 defines group 4 as any one of Gleason 8 (grade group 4), PSA above 20 or stage T3, and group 5 as two or more of those three, or Gleason 9 to 10 (grade group 5), or stage T4. Active surveillance is not offered in either (1.3.11); radical prostatectomy or radical radiotherapy is offered where the cancer is likely to be controlled in the long term (1.3.12); radiotherapy is combined with androgen deprivation, and continuing it for up to three years is considered in CPG 4 and 5 (1.3.23); brachytherapy alone is not offered (1.3.25).
• Note what puts a man in group 4 on its own: a single T3, which means extraprostatic extension or seminal vesicle invasion. A stage found on MRI rather than by examination will be written cT3(mr) under the ninth edition of TNM, and the TNM committee's reason for introducing the suffix is precisely that imaging finds T3 disease a finger would have called T2.

The same record for scripts and assistants; checked 2026-09-25. Data CC BY-NC 4.0, attribute “Data from OnCo (onco.cc)”.