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This analysis of nearly 1,900 men introduced the low, intermediate and high-risk groups for localised prostate cancer based on PSA, Gleason score and stage, a classification still used to choose between surveillance, surgery and radiotherapy.
Retrospective cohort study of 1,872 men treated with radical prostatectomy, external beam radiotherapy or brachytherapy, stratified into low (PSA 10 or less, Gleason 6 or less, T1c to T2a), intermediate and high (PSA over 20, Gleason 8 to 10, or T2c) risk groups by five-year PSA failure.
Low-risk men had equivalent outcomes with all three treatments; intermediate- and high-risk men did worse with brachytherapy alone than with surgery or external beam radiotherapy.
The D'Amico system, refined by the NCCN, remains the framework for the very-low to very-high-risk categories used on this site's prostate pages.
Shares SPCG-4: radical prostatectomy or watchful waiting in prostate cancer, 29-year follow-up, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares SPCG-4: radical prostatectomy or watchful waiting in prostate cancer, 29-year follow-up, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares Measurement of prostate-specific antigen in serum as a screening test for prostate cancer, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Localised prostate cancer, high and very high risk.
Shares Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Localised prostate cancer, high and very high risk, Prostate cancer.
Shares Measurement of prostate-specific antigen in serum as a screening test for prostate cancer, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares SPCG-4: radical prostatectomy or watchful waiting in prostate cancer, 29-year follow-up, Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Prostate cancer roadmap: from Huggins and the discovery that a cancer can depend on a hormone, through the PSA epidemic and what it cost, the androgen receptor drugs, the DNA repair subset and PSMA, to a 2032 registry watch.
Shares Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Localised prostate cancer, high and very high risk, Prostate cancer.
Shares Localised prostate cancer, very low and low risk, Localised prostate cancer, intermediate risk, Prostate cancer.