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Trials
A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

trialsTrialRecruiting

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)

A phase 1/2 trial of Zidesamtinib in advanced solid tumours, run by Nuvalent Inc., now recruiting.

Also called: ARROS-1

Overview Connected5

Overview

A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1) is a phase 1/2 interventional study registered as NCT05118789 by Nuvalent Inc., with 359 participants planned, started 2022-01-04 and due to reach its primary completion in 2027-12-31. Interventions recorded: Zidesamtinib (NVL-520).

Setting

A Phase 1/2 Study of the Highly Selective ROS1 Inhibitor Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors (ARROS-1)

Phase

Phase 1/2

Sponsor

Nuvalent Inc.

Registry

Started

2022-01-04

Enrolled

359 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Small-molecule kinase inhibitors

targets

drugs

ApprovedSmall-molecule kinase inhibitor (ROS1)

Zidesamtinib · Jideytro

companies

Evidence strength26/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
359 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT05118789

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Small-molecule kinase inhibitors

Products

Zidesamtinib

Companies

Nuvalent

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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