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NVL (Nuclear valosin-containing protein-like) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.
In plain words · NVL (Nuclear valosin-containing protein-like) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
NVL (Nuclear valosin-containing protein-like) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways.
No product in this corpus aims at NVL yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1997. Earliest sequence paper UniProt cites for the protein: Germain-Lee E.L. et al, Genomics, 1997, "NVL: a new member of the AAA family of ATPases localized to the nucleus". Source.
Sources: HGNC HGNC:8070 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O15381 (protein name, function text, keywords and locations (REST API)); IntOGen NVL (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyses the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. Location: Nucleus, nucleoplasm; Nucleus, nucleolus (UniProt). Locus 1q42.11 (HGNC).
Query for this target: (TITLE:"NVL" OR ABSTRACT:"NVL" OR TITLE:"nuclear VCP like" OR ABSTRACT:"nuclear VCP like" OR TITLE:"Nuclear valosin-containing protein-like" OR ABSTRACT:"Nuclear valosin-containing protein-like" OR TITLE:"NVL2" OR ABSTRACT:"NVL2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NVL, not a curated reading list.