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Trials
To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

trialsTrialRecruiting

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation

A phase 2 trial of Lazertinib in advanced solid tumours, run by Abion Inc, now recruiting.

Overview Connected3

Overview

To Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-MET Dysregulation is a phase 2 interventional study registered as NCT05541822 by Abion Inc, with 178 participants planned, started 2023-01-17 and due to reach its primary completion in 2029-02. Interventions recorded: Vabametkib and Lazertinib.

Setting

A Phase 2 Multicenter, Open-Label, Parallel Cohort Expansion Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetic Profile of ABN401 in Patients With Advanced Solid Tumors Harboring c-Mesenchymal-epithelial Transition Factor (c-MET) Dysregulation

Phase

Phase 2

Sponsor

Abion Inc

Registry

Started

2023-01-17

Enrolled

178 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule kinase inhibitor (EGFR)

Lazertinib · Lazcluze

Evidence strength31/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
178 enrolled+11
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-25 · Jude Gomila · One thing, one id · diff · file

Sources & links

ClinicalTrials.gov NCT05541822

Data

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Metastatic cancer (cancer that has spread)

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Small-molecule kinase inhibitors

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Lazertinib

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