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Trials
A Study of Evaluating The Effects Of Pyrotinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer

trialsTrialActive

A Study of Evaluating The Effects Of Pyrotinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer

A phase 3 trial of Pyrotinib in advanced solid tumours, run by Jiangsu HengRui Medicine Co., Ltd., active and no longer recruiting.

Overview Connected4

Overview

A Study of Evaluating The Effects Of Pyrotinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer is a phase 3 interventional study registered as NCT03980054 by Jiangsu HengRui Medicine Co., Ltd., with 2135 participants enrolled, started 2019-07-12 and due to reach its primary completion in 2027-06. Interventions recorded: Pyrotinib and Placebo.

Setting

A Phase III Study to Evaluate the Efficacy and Safety of Pyrotinib Versus Placebo in Patients With Human Epidermal Growth Factor Receptor 2 (HER2) Positive Early or Locally Advanced Breast Cancer After Adjuvant Trastuzumab

Phase

Phase 3

Sponsor

Jiangsu HengRui Medicine Co., Ltd.

Registry

Started

2019-07-12

Enrolled

2,135 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule irreversible pan-HER kinase inhibitor

Pyrotinib · Airuini

companies

Jiangsu Hengrui Pharmaceuticals

Evidence strength52/100 · Solid

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
2,135 enrolled+17
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT03980054

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Small-molecule kinase inhibitors

Products

Pyrotinib

Companies

Jiangsu Hengrui Pharmaceuticals

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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