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Trials
A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

trialsTrialActive

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib

A phase 3 trial of Zanubrutinib and Tislelizumab in advanced solid tumours, run by BeOne Medicines, active and no longer recruiting.

Overview Connected5

Overview

A Study to Evaluate Long-term Safety of Zanubrutinib Regimens in Participants With B-Cell Malignancies Who Participated in BeiGene Parent Studies of Zanubrutinib is a phase 3 interventional study registered as NCT04170283 by BeOne Medicines, with 955 participants enrolled, started 2020-01-16 and due to reach its primary completion in 2026-12-31. Interventions recorded: Zanubrutinib and Tislelizumab.

Setting

An Open-label, Multi-center, Long-term Extension Study of Zanubrutinib (BGB-3111) Regimens in Patients With B-cell Malignancies

Phase

Phase 3

Sponsor

BeOne Medicines

Registry

Started

2020-01-16

Enrolled

955 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Small-molecule kinase inhibitors

drugs

ApprovedMonoclonal antibody (anti-PD-1)

Tislelizumab · Tevimbra

ApprovedSmall-molecule covalent BTK inhibitor (second generation)

Zanubrutinib · Brukinsa

companies

BeOne Medicines (formerly BeiGene)

Evidence strength50/100 · Solid

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
955 enrolled+15
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT04170283

Data

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Small-molecule kinase inhibitors

Products

Zanubrutinib
Tislelizumab

Companies

BeOne Medicines (formerly BeiGene)

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

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