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Trials
A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

trialsTrialRecruiting

A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL

A phase 1/2 trial of Zanubrutinib in diffuse large B-cell lymphoma, run by Genfleet Therapeutics (Shanghai) Inc., now recruiting.

Overview Connected4

Overview

A Study of GFH009 in Combination With Zanubrutinib in Subjects With Relapsed or Refractory DLBCL is a phase 1/2 interventional study registered as NCT06375733 by Genfleet Therapeutics (Shanghai) Inc., with 51 participants planned, started 2024-03-20 and due to reach its primary completion in 2026-12-31. Interventions recorded: GFH009 and Zanubrutinib.

Setting

A Phase Ib/II, Multicenter, Open-label, Single-arm Study to Assess the Safety and Efficacy of GFH009 in Combination With Zanubrutinib in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma (DLBCL)

Phase

Phase 1/2

Sponsor

Genfleet Therapeutics (Shanghai) Inc.

Registry

Started

2024-03-20

Enrolled

51 enrolled

Connected

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cancers

Diffuse large B-cell lymphoma

technologies

Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule covalent BTK inhibitor (second generation)

Zanubrutinib · Brukinsa

companies

GenFleet Therapeutics

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
51 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT06375733

Data

JSON ·

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Cancers

Diffuse large B-cell lymphoma

Technologies

Small-molecule kinase inhibitors

Products

Zanubrutinib

Companies

GenFleet Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

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