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Trials
A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

trialsTrialRecruiting

A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

A phase 1/2 trial of GFH375 in advanced solid tumours, run by Genfleet Therapeutics (Shanghai) Inc., now recruiting.

Overview Connected3

Overview

A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations is a phase 1/2 interventional study registered as NCT06500676 by Genfleet Therapeutics (Shanghai) Inc., with 407 participants planned, started 2024-07-09 and due to reach its primary completion in 2028-07-31. Interventions recorded: GFH375.

Setting

An Open-Label, Phase I/II Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of GFH375 in Patients With KRAS G12D Mutant Advanced Solid Tumors

Phase

Phase 1/2

Sponsor

Genfleet Therapeutics (Shanghai) Inc.

Registry

Started

2024-07-09

Enrolled

407 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

drugs

Phase 3small molecule (structure undisclosed or not yet in PubChem)

companies

GenFleet Therapeutics

Evidence strength21/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
407 enrolled+13
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Orphan trials · diff · file

Sources & links

ClinicalTrials.gov NCT06500676

Data

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Cancers

Metastatic cancer (cancer that has spread)

Products

GFH375

Companies

GenFleet Therapeutics

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