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Trials
Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.

trialsTrialRecruiting

Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.

A phase 2 trial of SPH4336 in brain and spinal cord tumours, run by Shanghai Pharmaceuticals Holding Co., Ltd, now recruiting.

Overview Connected4

Overview

Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases. is a phase 2 interventional study registered as NCT05872347 by Shanghai Pharmaceuticals Holding Co., Ltd, with 52 participants planned, started 2023-09-19 and due to reach its primary completion in 2026-12-31. Interventions recorded: SPH4336 Tablets.

Setting

A Phase II Study of SPH4336 in Combination With Endocrine Therapy in HR-positive, HER2-negative Breast Cancer Patients With Brain Metastases.

Phase

Phase 2

Sponsor

Shanghai Pharmaceuticals Holding Co., Ltd

Registry

Started

2023-09-19

Enrolled

52 enrolled

Connected

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cancers

Brain and spinal cord tumours (all types)Brain metastases (secondary brain tumours)

drugs

Phase 3small molecule

companies

GenFleet Therapeutics

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 2+15
52 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Link 1,018 registry trials to cancer subtype pages by dri… · diff · file

Sources & links

ClinicalTrials.gov NCT05872347

Data

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Cancers

Brain and spinal cord tumours (all types)
Brain metastases (secondary brain tumours)

Products

SPH4336

Companies

GenFleet Therapeutics

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

Machine-readable versions of Efficacy and Safety of SPH4336 in Combination With Endocrine Therapy in Breast Cancer Patients With Brain Metastases.

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