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Trials
A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children

trialsTrialActive

A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children

A phase 1/2 trial of Larotrectinib in advanced solid tumours, run by Bayer, active and no longer recruiting.

Also called: SCOUT

Overview Connected5

Overview

A Study to Test the Safety and Efficacy of the Drug Larotrectinib for the Treatment of Tumors With NTRK-fusion in Children is a phase 1/2 interventional study registered as NCT02637687 by Bayer, with 154 participants enrolled, started 2015-12-16 and due to reach its primary completion in 2024-07-20. Interventions recorded: Larotrectinib (Vitrakvi, BAY2757556).

Setting

A Phase 1/2 Study of the Oral TRK Inhibitor Larotrectinib in Pediatric Patients With Advanced Solid or Primary Central Nervous System Tumors

Phase

Phase 1/2

Sponsor

Bayer

Registry

Started

2015-12-16

Enrolled

154 enrolled

Connected

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cancers

Metastatic cancer (cancer that has spread)

technologies

Comprehensive genomic profiling Small-molecule kinase inhibitors

drugs

ApprovedSmall-molecule pan-TRK inhibitor (first generation)

Larotrectinib · Vitrakvi

companies

Evidence strength24/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
154 enrolled+11
No structured primary endpoint0
Result: active0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 2 corpus-only joins applied · diff · file

Sources & links

ClinicalTrials.gov NCT02637687

Data

JSON ·

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Cancers

Metastatic cancer (cancer that has spread)

Technologies

Comprehensive genomic profiling
Small-molecule kinase inhibitors

Products

Larotrectinib

Companies

Bayer

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

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