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Excess body fat is an established cause of thirteen cancers on the IARC list, including womb, oesophagus, kidney, liver, bowel, pancreas and postmenopausal breast cancer. It accounts for roughly 4 to 8% of cancers in high-income countries, second only to smoking among preventable causes, and bariatric surgery cohorts suggest the risk is partly reversible.
The IARC Handbook Working Group (2016) found sufficient evidence for cancers of the oesophagus (adenocarcinoma), gastric cardia, colon and rectum, liver, gallbladder, pancreas, postmenopausal breast, endometrium, ovary, kidney, meningioma, thyroid and multiple myeloma. Relative risks per 5 kg/m2 range from about 1.1 (breast) to 1.5-1.6 (endometrium, oesophageal adenocarcinoma). Mechanisms: insulin and IGF-1, sex hormones, adipokines and chronic inflammation. Population-attributable fractions are 4-8% of cancers in high-income countries and rising; bariatric surgery cohorts show the risk is at least partly reversible.
Showing the technology this term belongs to: GLP-1 receptor agonists and obesity-related cancer risk.
Shares GLP-1 receptor agonists as adjuvant weight-loss therapy in HR-positive breast cancer, Link bariatric and GLP-1 registries to cancer registries in every country that has both, GLP-1 receptor agonists and obesity-related cancer risk, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, Thyroid cancer, Endometrial cancer.
Shares Ultra-processed food and sugar-sweetened drinks, Energy balance, Lipid synthesis, uptake & cholesterol, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares Ultra-processed food (NOVA group 4), Ultra-processed food and sugar-sweetened drinks, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, International Agency for Research on Cancer (IARC / WHO).
Shares Metabolic syndrome and insulin resistance, Energy balance, Structured exercise programmes after curative treatment, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares Metabolic syndrome and insulin resistance, Ultra-processed food and sugar-sweetened drinks, Energy balance, Endometrial cancer.
Shares Risk factor, International Agency for Research on Cancer (IARC / WHO), Prevention we already have is not deployed, Oesophageal cancer.
Shares Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed, Oesophageal cancer.