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Following more than 900,000 American adults for 16 years, this study linked higher body weight to death from a wide range of cancers and estimated that excess weight could account for roughly one in seven cancer deaths in men and one in five in women in the United States.
Using the American Cancer Society's Cancer Prevention Study II, Calle and colleagues followed more than 900,000 adults who were cancer-free at enrolment in 1982 through 1998 and recorded 57,145 cancer deaths. Death rates from cancer rose with body mass index across most cancer sites, including cancers of the oesophagus, colon and rectum, liver, gallbladder, pancreas, kidney, stomach and prostate in men and breast, uterus, cervix and ovary in women. The heaviest participants had cancer death rates about half again higher than people of normal weight, and the authors estimated the share of US cancer deaths attributable to overweight and obesity.
This is the study most often cited for the size of the obesity and cancer link, and it broadened the list of weight-related cancers well beyond the few known before. It underlies weight management advice in cancer prevention guidance and the current interest in whether GLP-1 drugs change cancer risk.
Shares Mortality, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma, Colorectal cancer.
Shares Mortality, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma, Colorectal cancer.
Shares Obesity-related cancers (IARC list of 13), Endometrial cancer, Renal cell carcinoma, Hepatocellular carcinoma.
Shares Obesity-related cancers (IARC list of 13), Endometrial cancer, Hepatocellular carcinoma, Pancreatic ductal adenocarcinoma.
Shares Obesity-related cancers (IARC list of 13), Endometrial cancer, Renal cell carcinoma, Hepatocellular carcinoma.
Shares Mortality, Hepatocellular carcinoma, Colorectal cancer.
Shares Risk factor, Hepatocellular carcinoma, Colorectal cancer.
Shares Obesity-related cancers (IARC list of 13), Endometrial cancer, Renal cell carcinoma, Hepatocellular carcinoma.