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People with severe obesity who have weight-loss surgery develop about a third fewer cancers over the following decade, especially womb and other hormone-related cancers, than similar people who do not.
The Swedish Obese Subjects study (prospective, matched controls, more than 20 years' follow-up) and several large cohorts (SPLENDID, Cleveland Clinic, JAMA 2022, n=30,318) show that bariatric surgery is associated with a roughly 30-35% reduction in obesity-associated cancer incidence and lower cancer mortality, with the largest effects in endometrial cancer and in women. This is the strongest evidence that deliberately reversing obesity reduces cancer, though it remains non-randomised: no trial has randomised surgery with cancer as the outcome and the populations that undergo surgery differ from those that do not. A small increase in colorectal cancer risk after some procedures has been reported in Scandinavian registries and is unexplained. Whether GLP-1 receptor agonists reproduce the effect at scale is the live question.
Substantial, sustained weight loss lowers circulating insulin, oestrogens and inflammatory cytokines and reverses the metabolic and endometrial changes that drive obesity-related carcinogenesis.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One technology page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
Query for this technology: (TITLE:"Bariatric surgery and cancer incidence" OR ABSTRACT:"Bariatric surgery and cancer incidence") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bariatric surgery and cancer incidence, not a curated reading list.
Shares Link bariatric and GLP-1 registries to cancer registries in every country that has both, GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment.
Shares GLP-1 receptor agonists and obesity-related cancer risk, Chemoprevention & risk-reducing surgery, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Prevention we already have is not deployed.
Shares Obesity-related cancers (IARC list of 13), Endometrial cancer, Renal cell carcinoma, Hepatocellular carcinoma.
Shares Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed, Hepatocellular carcinoma.
Shares Chemoprevention & risk-reducing surgery, Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed.
Shares Prevention we already have is not deployed, Endometrial cancer, Renal cell carcinoma, Hepatocellular carcinoma.
Shares Obesity-related cancers (IARC list of 13), Diet, exercise and lifestyle roadmap: causes established → interventions that disappointed → exercise proven as treatment, Prevention we already have is not deployed, Hepatocellular carcinoma.
Shares Chemoprevention & risk-reducing surgery, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Prevention we already have is not deployed, HR-positive / HER2-negative breast cancer.