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Most people carrying a high-risk cancer gene do not know it until someone in the family gets cancer. Offer testing to all adults so carriers can be protected before that happens.
Family-history-based testing misses about half of BRCA and Lynch carriers. Population screening pilots (Ashkenazi BRCA programmes, Geisinger MyCode, Healthy Nevada) identify carriers efficiently and studies suggest cost-effectiveness at current sequencing prices. The proposal is national population screening for a defined panel of actionable hereditary cancer genes offered to all adults at a set age, with automated cascade testing offers to relatives, standardised risk-reducing pathways (enhanced surveillance, chemoprevention, risk-reducing surgery) and long-term outcome tracking.
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For women who carry a BRCA mutation, preventive removal of the ovaries and tubes saves lives, and preventive mastectomy almost eliminates breast cancer. These are the strongest prevention effects in oncology, which is why finding carriers before they develop cancer matters so much.
Shares PROSE consortium: preventive surgery lowers cancer and death in BRCA1 and BRCA2 carriers, National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Chemoprevention & risk-reducing surgery, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers.
Shares National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Germline vs somatic mutations, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Inherited risk is mostly unidentified.
Shares PROSE consortium: preventive surgery lowers cancer and death in BRCA1 and BRCA2 carriers, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD).
Shares National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing.
Shares National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Chemoprevention & risk-reducing surgery, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Inherited risk is mostly unidentified.
Shares National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Cancer prevention roadmap: tobacco control and vaccines → biomarker-guided chemoprevention → interception in carriers, Inherited risk is mostly unidentified, Germline (hereditary) testing.
Shares National Estimates of Genetic Testing in Women With a History of Breast or Ovarian Cancer, Inherited risk is mostly unidentified, Prevention we already have is not deployed, Germline (hereditary) testing.
Shares Chemoprevention & risk-reducing surgery, Germline vs somatic mutations, Inherited risk is mostly unidentified, Prevention we already have is not deployed.