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Among 2,482 women with BRCA1 or BRCA2 mutations, removing the ovaries and fallopian tubes was associated with 60% lower all-cause mortality, and no breast cancers occurred in the women who had preventive mastectomy.
The PROSE consortium followed 2,482 women with a BRCA1 or BRCA2 mutation at 22 centres in Europe and North America from 1974 to 2008, comparing outcomes in those who did and did not undergo risk-reducing mastectomy (RRM) or risk-reducing salpingo-oophorectomy (RRSO).
No breast cancers were diagnosed in the 247 women who had RRM over 3 years of follow-up, compared with 98 in the 1,372 who did not. RRSO was associated with lower risk of ovarian cancer, of first breast cancer in BRCA1 carriers, and with reduced all-cause mortality (10% vs 3%), breast cancer-specific mortality and ovarian cancer-specific mortality.
It was the first study to link risk-reducing surgery to a survival advantage and cemented RRSO as the standard recommendation for carriers by age 35-40 (BRCA1) or 40-45 (BRCA2).
For women who carry a BRCA mutation, preventive removal of the ovaries and tubes saves lives, and preventive mastectomy almost eliminates breast cancer. These are the strongest prevention effects in oncology, which is why finding carriers before they develop cancer matters so much.
Shares Susan M. Domchek, Germline vs somatic mutations, Inherited risk is mostly unidentified, Prevention we already have is not deployed.
Shares Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing, Ovarian cancer.
Shares Germline vs somatic mutations, Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing.
Shares Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing, Ovarian cancer.
Shares Germline vs somatic mutations, Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing.
Shares Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing, Ovarian cancer.
Shares Germline vs somatic mutations, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing, Ovarian cancer.
Shares Inherited risk is mostly unidentified, BRCA1 / BRCA2 (HRD), Germline (hereditary) testing, Ovarian cancer.