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ZMYM3 (Zinc finger MYM-type protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 4 more.
Required for regulation of cell morphology and cytoskeletal organisation.
Open Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.78, genetic association 0.00, somatic mutation 0.79). IntOGen calls it a driver in 15 cohorts (6 activating, 9 loss-of-function), covering Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Medulloblastoma, Prostate Adenocarcinoma and others.
In plain words · ZMYM3 (Zinc finger MYM-type protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 4 more.
ZMYM3 (Zinc finger MYM-type protein 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Breast cancer, Head and neck squamous cell carcinoma and 4 more.
Required for regulation of cell morphology and cytoskeletal organisation. Location: Nucleus (UniProt).
No product in this corpus aims at ZMYM3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: van der Maarel S.M. et al, Hum. Mol. Genet, 1996, "Cloning and characterization of DXS6673E, a candidate gene for X-linked mental retardation in Xq13.1". Source.
Sources: HGNC HGNC:13054 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14202 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147130 (association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: prostate cancer 0.57 (GraphQL API, CC0)); IntOGen ZMYM3 (driver in 15 cohorts (Act 6, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Required for regulation of cell morphology and cytoskeletal organisation. Location: Nucleus (UniProt). Locus Xq13.1 (HGNC).
Query for this target: (TITLE:"ZMYM3" OR ABSTRACT:"ZMYM3" OR TITLE:"zinc finger MYM-type containing 3" OR ABSTRACT:"zinc finger MYM-type containing 3" OR TITLE:"Zinc finger MYM-type protein 3" OR ABSTRACT:"Zinc finger MYM-type protein 3" OR TITLE:"ZNF198L2" OR ABSTRACT:"ZNF198L2" OR TITLE:"DXS6673E" OR ABSTRACT:"DXS6673E" OR TITLE:"KIAA0385" OR ABSTRACT:"KIAA0385") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZMYM3, not a curated reading list.
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Head and neck squamous cell carcinoma, Breast cancer (all types).
Shares Medulloblastoma, IntOGen, Open Targets Platform.
Shares Medulloblastoma, IntOGen, Breast cancer (all types), Open Targets Platform.
Shares Medulloblastoma, IntOGen, Prostate cancer.
Shares Thymoma (WHO types A, AB, B1, B2 and B3), IntOGen, Open Targets Platform.