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NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.61, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Ovarian Epithelial Tumour.
In plain words · NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.
No product in this corpus aims at NUTM1 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2003. Earliest sequence paper UniProt cites for the protein: French C.A. et al, Cancer Res, 2003, "BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma". Source.
Sources: HGNC HGNC:29919 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q86Y26 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184507 (association with cancer (MONDO_0004992) 0.66; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.53, melanoma 0.56, skin cancer 0.59, lung cancer 0.56 (GraphQL API, CC0)); IntOGen NUTM1 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Location: Cytoplasm; Nucleus (UniProt). Locus 15q14 (HGNC).
Query for this target: (TITLE:"NUTM1" OR ABSTRACT:"NUTM1" OR TITLE:"NUT midline carcinoma family member 1" OR ABSTRACT:"NUT midline carcinoma family member 1" OR TITLE:"NUT family member 1" OR ABSTRACT:"NUT family member 1" OR TITLE:"DKFZp434O192" OR ABSTRACT:"DKFZp434O192" OR TITLE:"FAM22H" OR ABSTRACT:"FAM22H" OR TITLE:"C15orf55" OR ABSTRACT:"C15orf55") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NUTM1, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Ovarian cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Open Targets Platform.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Lung cancer (all types).
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Open Targets Platform.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.