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CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.52, somatic mutation 0.90). IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Cholangiocarcinoma, Colon Adenocarcinoma, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Lung Squamous Cell Carcinoma, Stomach Adenocarcinoma.
In plain words · CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
CDH11 (Cadherin-11) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Gastric & gastro-oesophageal junction cancer, Colorectal cancer and 5 more.
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
No product in this corpus aims at CDH11 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1991. Earliest sequence paper UniProt cites for the protein: Suzuki et al, Cell Regul, 1991, "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Source.
Sources: HGNC HGNC:1750 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55287 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140937 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: gastric cancer 0.55, oesophageal cancer 0.54, skin cancer 0.51, breast cancer 0.53, biliary tract cancer 0.51 (GraphQL API, CC0)); IntOGen CDH11 (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration. Location: Cell membrane (UniProt). Locus 16q21 (HGNC).
Query for this target: (TITLE:"CDH11" OR ABSTRACT:"CDH11" OR TITLE:"cadherin 11" OR ABSTRACT:"cadherin 11" OR TITLE:"Cadherin-11" OR ABSTRACT:"Cadherin-11" OR TITLE:"CAD11" OR ABSTRACT:"CAD11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CDH11, not a curated reading list.
Shares Biliary tract cancer (all types), Oesophageal cancer, Skin cancer (all types), Hepatocellular carcinoma.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Hepatocellular carcinoma, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Biliary tract cancer (all types), Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Biliary tract cancer (all types), Oesophageal cancer, Hepatocellular carcinoma, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Biliary tract cancer (all types), Hepatocellular carcinoma, IntOGen, Gastric & gastro-oesophageal junction cancer.
Shares Biliary tract cancer (all types), Oesophageal cancer, Skin cancer (all types), IntOGen.