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KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more.
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, animal model 0.48, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Oesophageal Adenocarcinoma.
In plain words · KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more.
KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more.
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity.
No product in this corpus aims at KAT6A yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Borrow et al, Nat. Genet, 1996, "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Source.
Sources: HGNC HGNC:13013 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92794 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000083168 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: colorectal cancer 0.53, ovarian cancer 0.52, melanoma 0.56, skin cancer 0.57, breast cancer 0.55, lung cancer 0.53 (GraphQL API, CC0)); IntOGen KAT6A (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body (UniProt). Locus 8p11.21 (HGNC).
Query for this target: (TITLE:"KAT6A" OR ABSTRACT:"KAT6A" OR TITLE:"lysine acetyltransferase 6A" OR ABSTRACT:"lysine acetyltransferase 6A" OR TITLE:"Histone acetyltransferase KAT6A" OR ABSTRACT:"Histone acetyltransferase KAT6A" OR TITLE:"ZNF220" OR ABSTRACT:"ZNF220" OR TITLE:"RUNXBP2" OR ABSTRACT:"RUNXBP2" OR TITLE:"MYST3" OR ABSTRACT:"MYST3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT6A, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Ovarian cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Ovarian cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Breast cancer (all types).
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Breast cancer (all types).