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KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body (UniProt). Locus 8p11.21 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"KAT6A" OR ABSTRACT:"KAT6A" OR TITLE:"lysine acetyltransferase 6A" OR ABSTRACT:"lysine acetyltransferase 6A" OR TITLE:"Histone acetyltransferase KAT6A" OR ABSTRACT:"Histone acetyltransferase KAT6A" OR TITLE:"ZNF220" OR ABSTRACT:"ZNF220" OR TITLE:"RUNXBP2" OR ABSTRACT:"RUNXBP2" OR TITLE:"MYST3" OR ABSTRACT:"MYST3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about KAT6A, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/kat6a.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/kat6a.json. Licence CC BY-NC 4.0.