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CTNND2 (Catenin delta-2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma and 3 more.
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signalling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation.
IntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma.
In plain words · CTNND2 (Catenin delta-2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma and 3 more.
CTNND2 (Catenin delta-2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma and 3 more.
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signalling.
No product in this corpus aims at CTNND2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1996. Earliest sequence paper UniProt cites for the protein: Fraser P.E. et al, 1996, "A novel gene from the arm family". Source.
Sources: HGNC HGNC:2516 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UQB3 (protein name, function text, keywords and locations (REST API)); IntOGen CTNND2 (driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signalling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Location: Nucleus; Cell junction, adherens junction; Cell projection, dendrite; Perikaryon (UniProt). Locus 5p15.2 (HGNC).
Query for this target: (TITLE:"CTNND2" OR ABSTRACT:"CTNND2" OR TITLE:"catenin delta 2" OR ABSTRACT:"catenin delta 2" OR TITLE:"Catenin delta-2" OR ABSTRACT:"Catenin delta-2" OR TITLE:"NPRAP" OR ABSTRACT:"NPRAP" OR TITLE:"GT24" OR ABSTRACT:"GT24") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTNND2, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Ovarian cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Non-small-cell lung cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Ovarian cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Melanoma.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Melanoma.