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CANT1 (Soluble calcium-activated nucleotidase 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
Calcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP. In vitro, it can also act with low or negligible efficiency on ribonucletides triphosphate UTP, GTP, ITP, ATP and CTP. Does not hydrolyse AMP and GMP.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Adenocarcinoma.
In plain words · CANT1 (Soluble calcium-activated nucleotidase 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
CANT1 (Soluble calcium-activated nucleotidase 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
Calcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP.
No product in this corpus aims at CANT1 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2002. Earliest sequence paper UniProt cites for the protein: Smith et al, Arch. Biochem. Biophys, 2002, "Cloning, expression, and characterization of a soluble calcium-activated nucleotidase, a human enzyme belonging to a new family of extracellular nucleotidases". Source.
Sources: HGNC HGNC:19721 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8WVQ1 (protein name, function text, keywords and locations (REST API)); IntOGen CANT1 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Calcium-dependent nucleotidase with a preference for ribonucleosides diphosphate UDP, GDP and IDP, while having very low activity towards ADP and CDP. In vitro, it can also act with low or negligible efficiency on ribonucletides triphosphate UTP, GTP, ITP, ATP and CTP. Does not hydrolyse AMP and GMP. Involved in proteoglycan synthesis. Location: Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane; Cell membrane (UniProt). Locus 17q25.3 (HGNC).
Query for this target: (TITLE:"CANT1" OR ABSTRACT:"CANT1" OR TITLE:"calcium activated nucleotidase 1" OR ABSTRACT:"calcium activated nucleotidase 1" OR TITLE:"Soluble calcium-activated nucleotidase 1" OR ABSTRACT:"Soluble calcium-activated nucleotidase 1" OR TITLE:"SHAPY" OR ABSTRACT:"SHAPY" OR TITLE:"SCAN-1" OR ABSTRACT:"SCAN-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CANT1, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.