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ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
May be involved in transcriptional regulation.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Oesophageal Adenocarcinoma.
In plain words · ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
ZNF208 (Zinc finger protein 208) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer and Oesophageal and junctional adenocarcinoma.
May be involved in transcriptional regulation. Location: Nucleus (UniProt).
No product in this corpus aims at ZNF208 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1998. Earliest sequence paper UniProt cites for the protein: Eichler E.E. et al, Genome Res, 1998, "Complex beta-satellite repeat structures and the expansion of the zinc finger gene cluster in 19p12". Source.
Sources: HGNC HGNC:12999 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43345 (protein name, function text, keywords and locations (REST API)); IntOGen ZNF208 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
May be involved in transcriptional regulation. Location: Nucleus (UniProt). Locus 19p12 (HGNC).
Query for this target: (TITLE:"ZNF208" OR ABSTRACT:"ZNF208" OR TITLE:"zinc finger protein 208" OR ABSTRACT:"zinc finger protein 208" OR TITLE:"Zinc finger protein 208" OR ABSTRACT:"Zinc finger protein 208" OR TITLE:"PMIDP" OR ABSTRACT:"PMIDP" OR TITLE:"ZNF95" OR ABSTRACT:"ZNF95") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZNF208, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer.