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GRM3 (Metabotropic glutamate receptor 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Chromophobe renal cell carcinoma and 2 more.
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signalling inhibits adenylate cyclase activity.
IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Chromophobe Renal Cell Carcinoma, Oesophageal Adenocarcinoma, Melanoma.
In plain words · GRM3 (Metabotropic glutamate receptor 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Chromophobe renal cell carcinoma and 2 more.
GRM3 (Metabotropic glutamate receptor 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Chromophobe renal cell carcinoma and 2 more.
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.
No product in this corpus aims at GRM3 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1996. Earliest sequence paper UniProt cites for the protein: Makoff et al, Brain Res. Mol. Brain Res, 1996, "Molecular characterization and localization of human metabotropic glutamate receptor type 3". Source.
Sources: HGNC HGNC:4595 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14832 (protein name, function text, keywords and locations (REST API)); IntOGen GRM3 (driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signalling inhibits adenylate cyclase activity. Location: Cell membrane (UniProt). Locus 7q21.11-q21.12 (HGNC).
Query for this target: (TITLE:"GRM3" OR ABSTRACT:"GRM3" OR TITLE:"glutamate metabotropic receptor 3" OR ABSTRACT:"glutamate metabotropic receptor 3" OR TITLE:"Metabotropic glutamate receptor 3" OR ABSTRACT:"Metabotropic glutamate receptor 3" OR TITLE:"GPRC1C" OR ABSTRACT:"GPRC1C" OR TITLE:"mGlu3" OR ABSTRACT:"mGlu3" OR TITLE:"MGLUR3" OR ABSTRACT:"MGLUR3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GRM3, not a curated reading list.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Melanoma.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Melanoma.
Shares Oesophageal and junctional adenocarcinoma, Oesophageal cancer, IntOGen, Melanoma.
Shares Oesophageal and junctional adenocarcinoma, Renal cell carcinoma, Oesophageal cancer, IntOGen.