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GRM3 (Metabotropic glutamate receptor 3) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Renal cell carcinoma, Oesophageal cancer, Chromophobe renal cell carcinoma and 2 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signalling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signalling inhibits adenylate cyclase activity. Location: Cell membrane (UniProt). Locus 7q21.11-q21.12 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"GRM3" OR ABSTRACT:"GRM3" OR TITLE:"glutamate metabotropic receptor 3" OR ABSTRACT:"glutamate metabotropic receptor 3" OR TITLE:"Metabotropic glutamate receptor 3" OR ABSTRACT:"Metabotropic glutamate receptor 3" OR TITLE:"GPRC1C" OR ABSTRACT:"GPRC1C" OR TITLE:"mGlu3" OR ABSTRACT:"mGlu3" OR TITLE:"MGLUR3" OR ABSTRACT:"MGLUR3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GRM3, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/grm3.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/grm3.json. Licence CC BY-NC 4.0.